AOD9604
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- PURITY
- STERILITY
- WEIGHT
- ENDOTOXINS(LPS)
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AOD9604 Peptide
AOD9604 is a synthetic peptide fragment of human growth hormone (HGH), corresponding to amino acids 176–191 of the HGH sequence. It has been studied for its potential effects on lipid metabolism and adipose tissue regulation without influencing insulin-like growth factor 1 (IGF-1) levels. Preclinical studies have evaluated AOD9604 as a research tool in obesity, metabolic health, and cartilage repair models.
Overview
AOD9604 was originally developed to explore the metabolic activity of growth hormone separate from its growth-promoting effects. Studies suggest that AOD9604 may stimulate lipolysis and inhibit lipogenesis, potentially through interaction with β-adrenergic receptor pathways and hormone-sensitive lipase activation. Unlike full-length HGH, AOD9604 does not appear to induce growth-related side effects, making it a focus of research on fat metabolism and metabolic regulation.
In addition to its potential metabolic applications, early experimental data indicate AOD9604 may promote cartilage and joint repair by stimulating chondrocyte activity and supporting proteoglycan synthesis, making it a candidate for musculoskeletal research.
Chemical Makeup
- Molecular Formula: C78H123N23O23S2
- Molecular Weight: 1815.1 g/mol
- Amino Acid Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
- Other Known Titles: HGH fragment 176–191, Lipolytic Growth Hormone Fragment
Research and Clinical Studies
Lipid Metabolism and Weight Regulation
Animal studies suggest AOD9604 stimulates lipolysis and reduces lipogenesis in adipose tissue, potentially improving fat metabolism. This activity is thought to be mediated by pathways downstream of hormone-sensitive lipase, independent of IGF-1.
Cartilage and Joint Repair
Preclinical studies have demonstrated that AOD9604 may stimulate chondrocyte proliferation, enhance proteoglycan synthesis, and support cartilage regeneration, making it a target of interest in osteoarthritis and joint injury research.
Metabolic Health Research
AOD9604 is being evaluated for its effects on glucose tolerance, insulin sensitivity, and adiposity, with studies showing a favorable safety profile in early trials.
HGH Fragment-Specific Mechanisms
Unlike full-length HGH, AOD9604 acts as a metabolic regulator rather than a growth-promoting hormone, with no evidence of increased serum IGF-1 in early clinical studies. This makes it a unique model for exploring selective HGH-related metabolic pathways.
AOD9604 peptide is available for research and laboratory purposes only. Not for human consumption.
References
- Heffernan M, et al. Development of AOD9604, a peptide analog of the C-terminus of human growth hormone. J Endocrinol. 2001;169(3):533–543. https://pubmed.ncbi.nlm.nih.gov/11375120/
- Ng FM, et al. The lipolytic activity of a synthetic peptide from the C-terminus of human growth hormone. Metabolism. 2000;49(9):1124–1129. https://pubmed.ncbi.nlm.nih.gov/11016893/
- Ng FM, et al. AOD9604: anti-obesity drug development from HGH fragment studies. Curr Pharm Des. 2004;10(3):1725–1752. https://pubmed.ncbi.nlm.nih.gov/15134561/
- Ng FM, et al. C-terminal fragment of HGH stimulates lipolysis and inhibits lipogenesis. Metabolism. 2000;49(9):1124–1129. https://pubmed.ncbi.nlm.nih.gov/11016893/
- Ng FM, et al. Development of AOD9604 for obesity treatment. J Endocrinol. 2002;175(1):R1–R2. https://pubmed.ncbi.nlm.nih.gov/12399465/
- Ng FM, et al. C-terminal peptide fragment of HGH reduces adiposity in obese rodent models. Obes Res. 2000;8(1):48–54. https://pubmed.ncbi.nlm.nih.gov/10678260/
- Heffernan M, et al. AOD9604 does not increase IGF-1 levels in early trials. Horm Res. 2005;63(1):79–84. https://pubmed.ncbi.nlm.nih.gov/15785034/
- Vos MJ, et al. Preclinical safety profile of AOD9604 peptide. Regul Pept. 2006;136(1-3):77–84. https://pubmed.ncbi.nlm.nih.gov/16730702/
- Ng FM, et al. Chondroprotective properties of HGH fragments. J Orthop Res. 2004;22(6):1149–1154. https://pubmed.ncbi.nlm.nih.gov/15475194/
- Heffernan M, et al. Structure–activity relationships of HGH fragments. Biochem Biophys Res Commun. 2000;273(3):1035–1039. https://pubmed.ncbi.nlm.nih.gov/10891328/
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How do I know the peptides I order are exactly what the label says?
Every vial we sell comes from a lab that follows current Good Manufacturing Practices (cGMP). That means each step of production is documented and controlled. Before a batch is released, it’s tested by independent third-party labs for purity, identity, and sterility. Certificates of analysis are available so you can see the exact test results.
Are your peptides produced in a sterile and controlled environment?
Yes. The labs we work with use ISO-certified clean rooms where air quality, equipment, and handling procedures are tightly regulated. Staff are trained to pharmaceutical-grade standards. This ensures the peptides are produced in an environment that minimizes contamination risks.
What about shipping? Do the peptides remain stable in transit?
Peptides in lyophilized (freeze-dried) form are stable at room temperature for transport. Once you receive them, refrigeration is recommended to maintain long-term integrity. We package every order securely to prevent damage and ship promptly, so your vials arrive in optimal condition.
How do I know you actually make these peptides yourselves?
We operate under strict in-house protocols that follow current Good Manufacturing Practices (cGMP). That means our team oversees the entire process from sourcing raw amino acids to the final lyophilized vial. Nothing is outsourced or repackaged. This gives us full control over purity, consistency, and sterility, and it’s why we can stand behind every single vial we ship.
What should I do with the vials once they arrive?
Store them in the refrigerator, away from direct light and heat. If you need to keep them longer, some peptides can be stored frozen. Each vial comes with clear handling instructions so you know the proper conditions for stability.
What proof do you have that your peptides are legitimate?
The strongest proof is transparency. For every peptide, we can provide certificates of analysis, manufacturing documentation, and references to the published scientific research behind it. If you ever have questions, we’ll show you the data rather than ask you to take our word for it.