GHRP-2
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Size: 5mg, 10mg
Contents: GHRP-2 (Growth Hormone Releasing Peptide-2)
Form: Powder
Purity: 99.3%
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- PURITY
- STERILITY
- WEIGHT
- ENDOTOXINS(LPS)
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GHRP-2 (Growth Hormone Releasing Peptide-2)
GHRP-2 is a synthetic hexapeptide that functions as a potent agonist of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a). It stimulates the release of growth hormone (GH) from the anterior pituitary through both hypothalamic and pituitary mechanisms. GHRP-2 is widely used in endocrinology and metabolism research as a reference compound for studying GH regulation, ghrelin signaling, appetite control, and anabolic pathways.
Overview
GHRP-2 (D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂) is one of the second-generation growth hormone secretagogues (GHS), developed to enhance potency and receptor selectivity relative to GHRP-6. It binds GHS-R1a independently of endogenous growth hormone-releasing hormone (GHRH), activating intracellular calcium mobilization and PKC signaling, leading to GH secretion.
Research indicates GHRP-2 increases circulating GH and IGF-1 levels, stimulates appetite, promotes lean body mass accrual, and enhances metabolic and regenerative processes in experimental systems.
Chemical Makeup
- Molecular Formula: C45H55N9O6
- Molecular Weight: 817.0 g/mol
- Amino Acid Sequence: D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂
- Compound Class: Synthetic hexapeptide; GHS-R1a agonist
- Form: Lyophilized powder
- Purity: ≥99% (per COA)
- Sizes Available: 5 mg and 10 mg vials
Research and Clinical Studies
Growth Hormone Secretion
GHRP-2 activates pituitary somatotrophs and hypothalamic neurons to induce GH release via ghrelin receptor stimulation. In both in vitro and in vivo models, it demonstrates strong and consistent GH secretory potency.
Synergism with GHRH
When co-administered with GHRH analogs or CJC-1295, GHRP-2 produces synergistic GH responses due to complementary signaling pathways (GHS-R1a and GHRH-R).
Metabolic and Anabolic Research
GHRP-2 elevates plasma IGF-1 and enhances nitrogen retention and protein synthesis. Research indicates potential benefits in tissue repair, muscle preservation, and metabolic rate enhancement under catabolic stress.
Neuroendocrine and Appetite Studies
Through ghrelin receptor activation, GHRP-2 influences feeding behavior and energy homeostasis, making it a model compound for studying appetite regulation and hypothalamic neuroendocrine control.
Mechanism and Pharmacokinetics
GHRP-2 has a short plasma half-life (~15–30 minutes) with rapid onset of GH release. Unlike ghrelin, it lacks lipid modifications, improving stability and ease of synthesis for laboratory applications.
GHRP-2 peptide is available for research and laboratory purposes only. Not for human consumption.
References
- Bowers CY, et al. Synthetic hexapeptides that stimulate GH release in vitro and in vivo. Endocrinology. 1990;126(1):122–127. https://pubmed.ncbi.nlm.nih.gov/2293977/
- Howard AD, et al. A receptor in pituitary and hypothalamus for growth hormone-releasing peptides. Science. 1996;273(5277):974–977. https://pubmed.ncbi.nlm.nih.gov/8688086/
- Smith RG, et al. Growth hormone secretagogues and GHS-R1a signaling. Endocr Rev. 2005;26(3):313–324. https://pubmed.ncbi.nlm.nih.gov/15871981/
- Bowers CY. Discovery of GHRP family peptides. Endocr Rev. 1998;19(6):801–822. https://pubmed.ncbi.nlm.nih.gov/9861543/
- Korbonits M, Grossman AB. Growth hormone secretagogues: clinical and preclinical data. Clin Endocrinol (Oxf). 1999;51(6):711–726. https://pubmed.ncbi.nlm.nih.gov/10619985/
- Fairhall KM, et al. Mechanistic insights into GH release by GHRP-2. J Endocrinol. 2000;165(1):133–141. https://pubmed.ncbi.nlm.nih.gov/10750046/
- Popovic V, et al. Endocrine effects of GHRP-2 administration in humans. J Clin Endocrinol Metab. 1995;80(11):3569–3575. https://pubmed.ncbi.nlm.nih.gov/7593427/
- Camanni F, et al. Synergistic GH release with GHRP-2 and GHRH. J Clin Endocrinol Metab. 1998;83(4):1229–1232. https://pubmed.ncbi.nlm.nih.gov/9543158/
- Smith RG, et al. GHS and ghrelin receptor mechanisms in energy balance. Nat Rev Endocrinol. 2012;8(7):451–462. https://pubmed.ncbi.nlm.nih.gov/22547182/
- Bowers CY, et al. Comparative potency of GHRP-2 and GHRP-6 in GH stimulation. Peptides. 1993;14(5):755–760. https://pubmed.ncbi.nlm.nih.gov/8216927/
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How do I know the peptides I order are exactly what the label says?
Every vial we sell comes from a lab that follows current Good Manufacturing Practices (cGMP). That means each step of production is documented and controlled. Before a batch is released, it’s tested by independent third-party labs for purity, identity, and sterility. Certificates of analysis are available so you can see the exact test results.
Are your peptides produced in a sterile and controlled environment?
Yes. The labs we work with use ISO-certified clean rooms where air quality, equipment, and handling procedures are tightly regulated. Staff are trained to pharmaceutical-grade standards. This ensures the peptides are produced in an environment that minimizes contamination risks.
What about shipping? Do the peptides remain stable in transit?
Peptides in lyophilized (freeze-dried) form are stable at room temperature for transport. Once you receive them, refrigeration is recommended to maintain long-term integrity. We package every order securely to prevent damage and ship promptly, so your vials arrive in optimal condition.
How do I know you actually make these peptides yourselves?
We operate under strict in-house protocols that follow current Good Manufacturing Practices (cGMP). That means our team oversees the entire process from sourcing raw amino acids to the final lyophilized vial. Nothing is outsourced or repackaged. This gives us full control over purity, consistency, and sterility, and it’s why we can stand behind every single vial we ship.
What should I do with the vials once they arrive?
Store them in the refrigerator, away from direct light and heat. If you need to keep them longer, some peptides can be stored frozen. Each vial comes with clear handling instructions so you know the proper conditions for stability.
What proof do you have that your peptides are legitimate?
The strongest proof is transparency. For every peptide, we can provide certificates of analysis, manufacturing documentation, and references to the published scientific research behind it. If you ever have questions, we’ll show you the data rather than ask you to take our word for it.