PT-141 Peptide
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PT-141 Peptide – 10mg
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH). It is a melanocortin receptor agonist with activity at MC3R and MC4R, studied for its effects on sexual behavior, central nervous system pathways, and melanocortin signaling. Unlike earlier melanocortin-based compounds, PT-141 has no significant activity at the MC1R receptor responsible for pigmentation, making it a distinct research tool for evaluating central melanocortin pathways.
Overview
PT-141 was developed through structural modification of the α-MSH analog melanotan II, optimizing its activity on central melanocortin receptors involved in sexual function and energy homeostasis. Preclinical studies have shown that PT-141 acts on hypothalamic neurons to regulate sexual behavior, arousal, and appetite pathways. It has been investigated in models of sexual dysfunction, metabolic regulation, and neuroendocrine signaling, with ongoing interest in its role in central nervous system research.
Chemical Makeup
- Molecular Formula: C50H68N14O10
- Molecular Weight: 1025.2 g/mol
- Amino Acid Sequence: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-OH (cyclic lactam)
- Other Known Titles: Bremelanotide, PT141 Peptide, Melanocortin Receptor Agonist
Research and Clinical Studies
Melanocortin System and Sexual Function
Animal studies have shown that PT-141 activates MC3R and MC4R receptors in the hypothalamus, resulting in enhanced sexual arousal and copulatory behavior in male and female models. Unlike phosphodiesterase type 5 inhibitors (PDE5i), PT-141 exerts its effects centrally rather than peripherally, making it a model compound for studying neuroendocrine sexual signaling.
Neuroendocrine and Appetite Regulation
The melanocortin system plays a key role in energy balance, and PT-141 has been studied for its influence on appetite suppression and body weight regulation in rodent models.
CNS Pharmacology and Safety
PT-141’s blood-brain barrier permeability and receptor selectivity have led to interest in its application for neuroendocrine and metabolic research. Early safety studies indicate a favorable pharmacological profile when administered intranasally or subcutaneously in controlled research settings.
Additional Research Applications
Exploratory studies have evaluated PT-141 for roles in ischemia protection, neuroinflammation modulation, and behavioral neuroscience research, making it a versatile model compound for melanocortin receptor biology.
PT-141 peptide is available for research and laboratory purposes only. Not for human consumption.
References
- Dorr RT, et al. Melanocortin receptor agonists and sexual function: discovery of PT-141. Ann N Y Acad Sci. 2003;994:96–102. https://pubmed.ncbi.nlm.nih.gov/12851312/
- Shadiack AM, et al. Melanocortin receptor agonists in sexual behavior research. Brain Res. 2007;1124(1):166–175. https://pubmed.ncbi.nlm.nih.gov/17118440/
- Hadley ME, et al. Discovery and development of melanocortin receptor ligands. Ann N Y Acad Sci. 2006;994:1–15. https://pubmed.ncbi.nlm.nih.gov/12851309/
- King SH, et al. PT-141: novel melanocortin analog in sexual arousal studies. J Sex Med. 2008;5(8):1939–1948. https://pubmed.ncbi.nlm.nih.gov/18624943/
- Giuliano F, et al. Central melanocortin pathways and erectile function. Int J Impot Res. 2007;19(1):17–23. https://pubmed.ncbi.nlm.nih.gov/17043692/
- Clayton AH, et al. Bremelanotide in female sexual dysfunction studies. J Sex Med. 2016;13(5):696–706. https://pubmed.ncbi.nlm.nih.gov/27045212/
- Wessells H, et al. Central melanocortin modulation of sexual function in humans. J Urol. 2000;164(3 Pt 1):738–743. https://pubmed.ncbi.nlm.nih.gov/10953129/
- van der Ploeg LH, et al. Melanocortin receptors and obesity research. Endocr Rev. 2002;23(6):728–743. https://pubmed.ncbi.nlm.nih.gov/12466191/
- Kask A, et al. Melanocortins in the brain: from pigmentation to appetite. Eur J Pharmacol. 1999;375(1-3):1–12. https://pubmed.ncbi.nlm.nih.gov/10443489/
- Wikberg JES, et al. Five subtypes of melanocortin receptors in energy homeostasis. Peptides. 1999;20(4):401–410. https://pubmed.ncbi.nlm.nih.gov/10328292/
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Every vial we sell comes from a lab that follows current Good Manufacturing Practices (cGMP). That means each step of production is documented and controlled. Before a batch is released, it’s tested by independent third-party labs for purity, identity, and sterility. Certificates of analysis are available so you can see the exact test results.
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Peptides in lyophilized (freeze-dried) form are stable at room temperature for transport. Once you receive them, refrigeration is recommended to maintain long-term integrity. We package every order securely to prevent damage and ship promptly, so your vials arrive in optimal condition.
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Store them in the refrigerator, away from direct light and heat. If you need to keep them longer, some peptides can be stored frozen. Each vial comes with clear handling instructions so you know the proper conditions for stability.
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