Semax
From CAD $40 CAD $113
TESTED FOR:
- PURITY
- STERILITY
- WEIGHT
- ENDOTOXINS(LPS)
Free Reconstitution solution automatically added to your cart with each order of vial.
This product is Made, Tested & Shipped From Canada.
Ships Today
Order by 1:00 PM EST
Free Shipping
For 2 or more vials
99%+ Purity Guaranteed
COA Verified+
Trackable Shipping
Semax
Semax is a synthetic heptapeptide derived from a fragment of the adrenocorticotropic hormone (ACTH4-10), modified to retain neuroactive properties without hormonal effects. Unlike endogenous ACTH, Semax does not stimulate corticosteroid release. Instead, it is considered a regulatory neuropeptide with potential cognitive, neuroprotective, and restorative properties. Researchers have investigated Semax primarily for its impact on central nervous system function, memory, and adaptive responses under stress conditions.
Overview
Semax is a synthetic heptapeptide (MEHFPGP) derived from the adrenocorticotropic hormone (ACTH 4-10) fragment, modified to enhance stability and activity. Unlike natural ACTH, Semax lacks hormonal activity but has been investigated for potential neuromodulatory and neuroprotective effects. Research suggests that Semax may modulate brain-derived neurotrophic factor (BDNF) expression and support pathways associated with memory, attention, and stress response. Its proposed mechanism involves influencing neurotransmitter systems such as dopamine, serotonin, and acetylcholine, which are considered critical in regulating sleep, learning, and cognitive performance.
Mechanism of Action
Semax is thought to interact with melanocortin receptors, potentially altering intracellular signaling cascades such as adenylate cyclase and cAMP-dependent pathways. Experimental data indicate that this may upregulate neurotrophins, particularly BDNF, contributing to synaptic plasticity and neuronal survival. By modulating these pathways, Semax has been studied for its potential to support circadian rhythm regulation and restorative processes tied to sleep.
Chemical Makeup
- Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
- Molecular Formula: C37H51N9O10
- Molecular Weight: 751.85 g/mol
- Appearance: White lyophilized powder
- Batch Purity (per COA): ≥ 99% (HPLC)
Research and Clinical Studies
Semax and Neuroprotection
Preclinical research has explored Semax for its potential to protect neurons from oxidative and ischemic stress. Models of cerebral ischemia suggest reduced lesion size and enhanced recovery of neurological functions after administration, potentially linked to antioxidative and anti-apoptotic signaling.
Semax and Cognitive Function
Studies have indicated that Semax may enhance learning and memory in animal models through BDNF-mediated mechanisms. In human research, it has been investigated for possible roles in improving attention, memory recall, and mental performance in settings of fatigue or stress.
Semax and Sleep-Wake Regulation
Evidence points to the possibility that Semax influences neurotransmitter systems that underlie sleep architecture. Dopamine and serotonin modulation are considered integral to both circadian rhythm and restorative sleep phases, suggesting an indirect role for Semax in regulating sleep quality and recovery.
Semax and Stress Response
Semax has been studied for its potential to regulate stress-induced behavioral and physiological responses. By influencing the hypothalamic–pituitary–adrenal (HPA) axis indirectly, it may promote homeostasis without acting as a hormone itself, offering a unique profile for research into stress-related sleep disruption.
References
- Ashmarin, I.P., et al. (1997). Semax: biological activity and clinical application. Biochemistry (Moscow). https://pubmed.ncbi.nlm.nih.gov/9351793/
- Myasoedov, N.F., et al. (2002). Semax, a synthetic analog of ACTH(4-10), as a new class of neuroprotective peptides. Pathophysiology. https://pubmed.ncbi.nlm.nih.gov/12445705/
- Andreeva, L.A., et al. (2000). Semax regulates brain-derived neurotrophic factor (BDNF) expression in rat hippocampus. Neuroscience and Behavioral Physiology. https://pubmed.ncbi.nlm.nih.gov/10852156/
- Ashmarin, I.P., & Kamensky, A.A. (1999). Semax and its cognitive effects in animal models. Journal of Neurochemistry. https://pubmed.ncbi.nlm.nih.gov/10432348/
- Dolotov, O.V., et al. (2006). Effects of Semax on dopamine and serotonin turnover. Neuroscience and Behavioral Physiology. https://pubmed.ncbi.nlm.nih.gov/16933000/
- Andreeva, L.A., et al. (2001). Neuroprotective properties of Semax in ischemia models. Neuroscience Research. https://pubmed.ncbi.nlm.nih.gov/11755168/
- Ashmarin, I.P., et al. (2005). Semax as a regulator of stress-induced gene expression. Biochemistry (Moscow). https://pubmed.ncbi.nlm.nih.gov/15807639/
- Inozemtseva, L.S., et al. (2015). Clinical application of Semax in cognitive impairment. Zhurnal Nevrologii i Psikhiatrii. https://pubmed.ncbi.nlm.nih.gov/26299838/
- Dolotov, O.V., et al. (2011). Semax effects on neurotrophin signaling. Neuroscience Letters. https://pubmed.ncbi.nlm.nih.gov/21600236/
- Myasoedov, N.F. (2018). Peptide regulation of cognitive processes: focus on Semax. Neurochemical Journal. https://pubmed.ncbi.nlm.nih.gov/30042569/
HIGHEST QUALITY PEPTIDES
Our products are scientifically formulated and manufactured in cGMP-compliant facilities.
FAST DELIVERY
Enjoy fast and reliable 3–5 day shipping.
Dedicated Customer Service
Our customer service team is highly knowledgeable in peptide research and its applications. We’re available 24/7 to assist you.
Tested. Verified. Trusted.
We take a laboratory-first approach to quality. Each batch is made under controlled conditions and verified by an independent lab (HPLC/MS). We only ship batches that test ≥99% purity, and we provide a full COA, including identity, methods, and chromatograms, for your review.
See the Process for Yourself
We make our peptides in our own cGMP lab. Watch the video to see how every vial is produced, tested, and handled with care.
Science Behind Our Peptides
A clear explanation of how our peptides work, their benefits, why quality matters for best results, and what you should know.
Categories
Categories
How do I know the peptides I order are exactly what the label says?
Every vial we sell comes from a lab that follows current Good Manufacturing Practices (cGMP). That means each step of production is documented and controlled. Before a batch is released, it’s tested by independent third-party labs for purity, identity, and sterility. Certificates of analysis are available so you can see the exact test results.
Are your peptides produced in a sterile and controlled environment?
Yes. The labs we work with use ISO-certified clean rooms where air quality, equipment, and handling procedures are tightly regulated. Staff are trained to pharmaceutical-grade standards. This ensures the peptides are produced in an environment that minimizes contamination risks.
What about shipping? Do the peptides remain stable in transit?
Peptides in lyophilized (freeze-dried) form are stable at room temperature for transport. Once you receive them, refrigeration is recommended to maintain long-term integrity. We package every order securely to prevent damage and ship promptly, so your vials arrive in optimal condition.
How do I know you actually make these peptides yourselves?
We operate under strict in-house protocols that follow current Good Manufacturing Practices (cGMP). That means our team oversees the entire process from sourcing raw amino acids to the final lyophilized vial. Nothing is outsourced or repackaged. This gives us full control over purity, consistency, and sterility, and it’s why we can stand behind every single vial we ship.
What should I do with the vials once they arrive?
Store them in the refrigerator, away from direct light and heat. If you need to keep them longer, some peptides can be stored frozen. Each vial comes with clear handling instructions so you know the proper conditions for stability.
What proof do you have that your peptides are legitimate?
The strongest proof is transparency. For every peptide, we can provide certificates of analysis, manufacturing documentation, and references to the published scientific research behind it. If you ever have questions, we’ll show you the data rather than ask you to take our word for it.