Sermorelin
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Contents: Sermorelin (Growth Hormone Releasing Hormone Analog)
Form: Powder
Purity: 99.3%
TESTED FOR:
- PURITY
- STERILITY
- WEIGHT
- ENDOTOXINS(LPS)
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Sermorelin
Sermorelin acetate is a synthetic analog of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). It functions as a selective stimulator of the GHRH receptor (GHRHR) on somatotroph cells of the anterior pituitary, initiating endogenous growth hormone (GH) release in a physiologic, pulsatile pattern. It is intended solely for laboratory and analytical research use, not for human or veterinary therapy.
Overview
In experimental systems, Sermorelin binds to GHRHR and triggers activation of intracellular adenylyl cyclase and cyclic AMP pathways, leading to increased transcription of the GH gene and secretion of GH into the circulation. The released GH may subsequently stimulate hepatic and peripheral production of insulin-like growth factor-1 (IGF-1). Because Sermorelin relies on pituitary responsiveness, it preserves natural feedback loops involving somatostatin and maintains endogenous GH axis integrity. Research interest includes endocrine modulation of GH, lean-mass and tissue-repair processes, fat metabolism, sleep physiology, and regenerative biology.
Chemical Composition
- Molecular Formula: C₁₄₉H₂₄₆N₄₄O₄₂S (free base)
- Theoretical Mass: 3,357.9 Da
- Observed Mass (Batch # 2025023): 3,357.9 Da (as determined by LCMS)
- Purity (HPLC, Batch # 2025023): 99.18 %
- Form: Lyophilized powder
- Analysis Method: Reverse-phase HPLC (UV 214 nm) and ESI-LCMS; calibrated with internal reference standard.
Research and Clinical Studies
GH-Axis Modulation
Early clinical application of Sermorelin showed effective stimulation of GH release in GH-deficient children and as a diagnostic agent for pituitary insufficiency. The compound triggers endogenous GH secretion rather than replacing GH directly, enabling a more physiologic release pattern.
Tissue Repair, Body Composition & Recovery
Preclinical and clinical research have explored Sermorelin’s potential impact on lean-body mass, fat reduction, bone health, and sleep quality. Although data are less robust outside GH-deficiency populations, the mechanism supports investigation of tissue-regenerative and recovery biology contexts.
Metabolism & Aging Research
Because GH and IGF-1 decline with aging, research prototypes have employed Sermorelin in models of metabolic decline, reduced muscle mass, and slowed tissue repair. While definitive evidence remains limited, the compound continues to serve as a tool reagent in endocrine, metabolic and gerontology research.
Summary
Sermorelin acetate (Batch # 2025023) exhibits a confirmed mass of 3,357.9 Da and purity of 99.18 % by HPLC. These analytical specifications verify the sample’s suitability for controlled laboratory research applications. Sermorelin remains an investigational peptide reagent intended strictly for research use, not for therapeutic or diagnostic use in humans or animals.
References
- Clarke IJ, Camanni F, Ghigo E. “Growth hormone-releasing hormone (GHRH): physiology and clinical applications.” Endocr Rev. 2004;25(5):688-701. https://pubmed.ncbi.nlm.nih.gov/15258118/
- Mondal P, Rai KM, Roy A. “GHRH and its analogs in growth hormone regulation: A review.” J Endocrinol Invest. 2003;26(1):29-34. https://pubmed.ncbi.nlm.nih.gov/12631116/
- Peptide Initiative. “Sermorelin: Mechanisms of Action.” 2023. https://www.peptideinitiative.com/peptides/sermorelin/research/mechanisms
- “Sermorelin: A review of its use in diagnosis and treatment of GH-deficiency.” BioDrugs. 1999;13(1):37-44. https://pubmed.ncbi.nlm.nih.gov/10366877/
- Mayo Clinic. “Sermorelin (injection route)-Description.” 2025. https://www.mayoclinic.org/drugs-supplements/sermorelin-injection-route/description/drg-20065923
- NCATS Drug Information. “Sermorelin (GHRH 1-29 analog).” 2025. https://drugs.ncats.io/drug/89243S03TE
- LabOfRAD. “The Gold Standard Peptide for Natural Growth Hormone Optimization.” 2024. https://www.labofrad.com/peptideinfo/sermorelin/
- Healthline. “What Is Sermorelin, and How Is It Used?” 2025. https://www.healthline.com/health/what-is-sermorelin-and-how-is-it-used
For research use only. Not for human or veterinary use.
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We take a laboratory-first approach to quality. Each batch is made under controlled conditions and verified by an independent lab (HPLC/MS). We only ship batches that test ≥99% purity, and we provide a full COA, including identity, methods, and chromatograms, for your review.
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How do I know the peptides I order are exactly what the label says?
Every vial we sell comes from a lab that follows current Good Manufacturing Practices (cGMP). That means each step of production is documented and controlled. Before a batch is released, it’s tested by independent third-party labs for purity, identity, and sterility. Certificates of analysis are available so you can see the exact test results.
Are your peptides produced in a sterile and controlled environment?
Yes. The labs we work with use ISO-certified clean rooms where air quality, equipment, and handling procedures are tightly regulated. Staff are trained to pharmaceutical-grade standards. This ensures the peptides are produced in an environment that minimizes contamination risks.
What about shipping? Do the peptides remain stable in transit?
Peptides in lyophilized (freeze-dried) form are stable at room temperature for transport. Once you receive them, refrigeration is recommended to maintain long-term integrity. We package every order securely to prevent damage and ship promptly, so your vials arrive in optimal condition.
How do I know you actually make these peptides yourselves?
We operate under strict in-house protocols that follow current Good Manufacturing Practices (cGMP). That means our team oversees the entire process from sourcing raw amino acids to the final lyophilized vial. Nothing is outsourced or repackaged. This gives us full control over purity, consistency, and sterility, and it’s why we can stand behind every single vial we ship.
What should I do with the vials once they arrive?
Store them in the refrigerator, away from direct light and heat. If you need to keep them longer, some peptides can be stored frozen. Each vial comes with clear handling instructions so you know the proper conditions for stability.
What proof do you have that your peptides are legitimate?
The strongest proof is transparency. For every peptide, we can provide certificates of analysis, manufacturing documentation, and references to the published scientific research behind it. If you ever have questions, we’ll show you the data rather than ask you to take our word for it.