Ara-290
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Contents: Ara-290 (Erythropoietin-Derived Peptide, Innate Repair Receptor Agonist)
Form: Powder
Purity: 99.3%
TESTED FOR:
- PURITY
- STERILITY
- WEIGHT
- ENDOTOXINS(LPS)
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Ara-290
Ara-290 is a synthetic peptide derived from a specific receptor-binding region of erythropoietin (EPO). It is investigated for its ability to interact with the heteromeric EPO receptor/CD131 complex implicated in inflammatory modulation and tissue protection. Research focuses on Ara-290’s potential to support cellular homeostasis by signaling through pathways distinct from those responsible for erythropoiesis.
Models of inflammatory and neuropathic stress are used to evaluate whether Ara-290 may influence immune responses, neuronal function, and endothelium-associated signaling without stimulating red blood cell proliferation.
Overview
Ara-290 has been examined for possible regulation of cytokine balance, responsiveness to cellular stress, and preservation of structural integrity in tissues affected by metabolic or injury-related stress. Investigators assess its impact on neural pain pathways, microvascular function, and protective biochemical cascades involving oxidative resilience and metabolic stabilization.
Chemical Makeup
Ara-290 is a short synthetic peptide engineered to selectively activate specific EPO receptor pathways. Due to variable peptide manufacturing parameters, a single definitive molecular formula is not listed. Batch identity is confirmed analytically.
- Observed Mass (MS): 711.9 Da
- Purity (HPLC): 99.42%
- Batch Number: 2025007
- Primary Retention Time: 3.48 min
- Instrument: LCMS-7800 Series (Calibrated)
- Analytical Note: Primary peak confirmed by mass and retention time; trace secondary peak area 0.58%
Research and Clinical Studies
Ara-290 and Neuroprotection Models
Experimental studies explore Ara-290’s potential to reduce inflammation-related neuronal stress and support functional signaling in peripheral and central nervous tissues.
Ara-290 and Inflammatory Pathways
Research examines how Ara-290 may influence cytokine expression profiles and mitigate immune-mediated tissue disruption under controlled conditions.
Ara-290 and Microvascular Function
Investigators evaluate whether receptor-specific signaling may stabilize endothelial behavior and influence perfusion in compromised tissues.
Ara-290 and Neuropathic Pain
Preclinical and controlled human studies investigate the modulation of pain-associated sensory pathways and alterations in discomfort severity during inflammatory states.
Ara-290 and Tissue Homeostasis
Laboratory studies continue to analyze interactions with cytoprotective pathways supporting resilience against metabolic or ischemic cellular disturbances.
Ara-290 research peptide is provided exclusively for laboratory investigation by qualified personnel. Not for human or veterinary administration.
References
- Brines M, Cerami A. The receptor-targeted protection of tissue by EPO-derived peptides. Nat Rev Drug Discov. 2012;11(9):697–707. PMID: 22935759.
https://pubmed.ncbi.nlm.nih.gov/22935759/
- Heij L, et al. Ara-290 in neuropathic pain: evaluation of clinical responses. Pain. 2012;153(7):1495–1502. PMID: 22541784.
https://pubmed.ncbi.nlm.nih.gov/22541784/
- Brines M, et al. Selective activation of the tissue-protective EPO receptor. J Clin Invest. 2004;114(9):1310–1318. PMCID: PMC521645.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC521645/
- Patel NS, et al. Anti-inflammatory peptide activity in metabolic injury models. Am J Pathol. 2010;177(2):1026–1035. PMID: 20581065.
https://pubmed.ncbi.nlm.nih.gov/20581065/
- Khan RS, et al. Cytokine modulation with EPO-derived peptides. Mol Med. 2014;20(1):58–65. PMCID: PMC3938790.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938790/
- Joosten EA, et al. Neuropathic signaling responses to Ara-290. Expert Opin Investig Drugs. 2016;25(2):1–10. PMID: 26762828.
https://pubmed.ncbi.nlm.nih.gov/26762828/
- ClinicalTrials.gov Identifier: NCT01965756. Anti-inflammatory properties of Ara-290 in neuropathic conditions.
https://clinicaltrials.gov/ct2/show/NCT01965756
- ClinicalTrials.gov Identifier: NCT02289729. Investigation of microvascular responses to EPO-derived peptides.
https://clinicaltrials.gov/ct2/show/NCT02289729
For Research Use Only. Not for human or veterinary use.
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We take a laboratory-first approach to quality. Each batch is made under controlled conditions and verified by an independent lab (HPLC/MS). We only ship batches that test ≥99% purity, and we provide a full COA, including identity, methods, and chromatograms, for your review.
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How do I know the peptides I order are exactly what the label says?
Every vial we sell comes from a lab that follows current Good Manufacturing Practices (cGMP). That means each step of production is documented and controlled. Before a batch is released, it’s tested by independent third-party labs for purity, identity, and sterility. Certificates of analysis are available so you can see the exact test results.
Are your peptides produced in a sterile and controlled environment?
Yes. The labs we work with use ISO-certified clean rooms where air quality, equipment, and handling procedures are tightly regulated. Staff are trained to pharmaceutical-grade standards. This ensures the peptides are produced in an environment that minimizes contamination risks.
What about shipping? Do the peptides remain stable in transit?
Peptides in lyophilized (freeze-dried) form are stable at room temperature for transport. Once you receive them, refrigeration is recommended to maintain long-term integrity. We package every order securely to prevent damage and ship promptly, so your vials arrive in optimal condition.
How do I know you actually make these peptides yourselves?
We operate under strict in-house protocols that follow current Good Manufacturing Practices (cGMP). That means our team oversees the entire process from sourcing raw amino acids to the final lyophilized vial. Nothing is outsourced or repackaged. This gives us full control over purity, consistency, and sterility, and it’s why we can stand behind every single vial we ship.
What should I do with the vials once they arrive?
Store them in the refrigerator, away from direct light and heat. If you need to keep them longer, some peptides can be stored frozen. Each vial comes with clear handling instructions so you know the proper conditions for stability.
What proof do you have that your peptides are legitimate?
The strongest proof is transparency. For every peptide, we can provide certificates of analysis, manufacturing documentation, and references to the published scientific research behind it. If you ever have questions, we’ll show you the data rather than ask you to take our word for it.