SLU-PP-322
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Contents: SLU-PP-322 (PPARδ/PPARα Modulator)
Form: Powder
Purity: 99.3%
TESTED FOR:
- PURITY
- STERILITY
- WEIGHT
- ENDOTOXINS(LPS)
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SLU-PP-332 – Pan-ERR Agonist (Exercise-Mimetic Compound)
SLU-PP-332 is a synthetic small-molecule agonist of the estrogen-related receptors (ERRα, ERRβ, and ERRγ)—nuclear receptors that regulate mitochondrial biogenesis, oxidative metabolism, and energy expenditure. It has been identified as a potent metabolic modulator capable of mimicking the molecular effects of endurance exercise. SLU-PP-332 is of growing interest in metabolic, mitochondrial, and exercise physiology research for its ability to reprogram energy metabolism in skeletal muscle and adipose tissue.
Overview
SLU-PP-332 acts as a pan-ERR agonist, binding with high affinity to all three ERR isoforms. Activation of these transcription factors induces expression of genes involved in mitochondrial oxidative phosphorylation, fatty acid β-oxidation, and tricarboxylic acid (TCA) cycle function.
In preclinical models, SLU-PP-332 increased mitochondrial density, enhanced endurance performance, improved glucose and lipid metabolism, and reduced body fat independent of food intake. These findings suggest the compound effectively simulates several biochemical adaptations typically associated with aerobic training.
Chemical Makeup
- Chemical Name: SLU-PP-332
- Molecular Formula: C18H14N2O2
- Molecular Weight: 290.32 g/mol
- Compound Class: Small-molecule ERR pan-agonist
- Mechanism: Direct activation of ERRα/β/γ nuclear receptors
- Form: Lyophilized solid
- Purity: ≥98% (per COA)
- CAS Number: 303760-60-3
Research and Experimental Applications
Mitochondrial Biogenesis and Energy Metabolism
SLU-PP-332 induces mitochondrial biogenic pathways via coactivation of PGC-1α and ERRα, leading to elevated mitochondrial content and oxidative enzyme expression in muscle and liver tissue.
Exercise-Mimetic and Endurance Models
In vivo studies demonstrate enhanced endurance and metabolic efficiency following SLU-PP-332 administration. Treated mice displayed increased aerobic capacity, improved substrate utilization, and elevated fatty acid oxidation markers.
Lipid and Glucose Homeostasis
The compound reduces fat accumulation and improves glucose tolerance by shifting energy metabolism toward oxidative pathways. This makes SLU-PP-332 a valuable tool for research in obesity, insulin resistance, and metabolic syndrome.
Muscle and Mitochondrial Health
By promoting oxidative fiber remodeling and upregulating mitochondrial enzymes, SLU-PP-332 supports research into sarcopenia, mitochondrial dysfunction, and aging-related energy deficits.
Mechanistic Studies
ERR activation by SLU-PP-332 modulates transcription of PGC-1α-dependent genes, including CPT1, MCAD, TFAM, and COX subunits, demonstrating broad mitochondrial and metabolic gene engagement.
SLU-PP-332 is available for research and laboratory purposes only. Not for human consumption.
References
- Billon GJ, et al. Synthetic ERRα/β/γ agonist induces an acute aerobic exercise response and enhances exercise capacity. ACS Chem Biol. 2023;18(6):756–768. https://pubmed.ncbi.nlm.nih.gov/36988910/
- Billon GJ, et al. Pharmacological activation of ERRs improves metabolic function and endurance in mice. J Pharmacol Exp Ther. 2024;388(2):232–243. https://pubmed.ncbi.nlm.nih.gov/37739806/
- Pino MF, et al. Estrogen-related receptors as regulators of mitochondrial metabolism. Trends Endocrinol Metab. 2018;29(8):496–509. https://pubmed.ncbi.nlm.nih.gov/29914871/
- Huss JM, Kelly DP. Nuclear receptor signaling and cardiac energetics. Circ Res. 2004;95(6):568–578. https://pubmed.ncbi.nlm.nih.gov/15358669/
- Mootha VK, et al. ERRα and PGC-1α coordinate mitochondrial oxidative metabolism. Proc Natl Acad Sci U S A. 2004;101(17):6570–6575. https://pubmed.ncbi.nlm.nih.gov/15087505/
- Schreiber SN, et al. The estrogen-related receptors and coactivators in energy metabolism. J Biol Chem. 2004;279(48):49330–49337. https://pubmed.ncbi.nlm.nih.gov/15371420/
- Bonnelye E, et al. ERR family in metabolic homeostasis. Mol Cell Endocrinol. 2020;505:110710. https://pubmed.ncbi.nlm.nih.gov/31837419/
- Kamei Y, et al. ERRs regulate skeletal muscle oxidative capacity. J Biol Chem. 2003;278(36):33995–34002. https://pubmed.ncbi.nlm.nih.gov/12807910/
- Giguère V. ERRs as metabolic regulators and drug targets. Endocr Rev. 2008;29(6):677–696. https://pubmed.ncbi.nlm.nih.gov/18664618/
- Tocris Bioscience. SLU-PP-332 product data. https://www.tocris.com/products/slu-pp-332_8112
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How do I know the peptides I order are exactly what the label says?
Every vial we sell comes from a lab that follows current Good Manufacturing Practices (cGMP). That means each step of production is documented and controlled. Before a batch is released, it’s tested by independent third-party labs for purity, identity, and sterility. Certificates of analysis are available so you can see the exact test results.
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Yes. The labs we work with use ISO-certified clean rooms where air quality, equipment, and handling procedures are tightly regulated. Staff are trained to pharmaceutical-grade standards. This ensures the peptides are produced in an environment that minimizes contamination risks.
What about shipping? Do the peptides remain stable in transit?
Peptides in lyophilized (freeze-dried) form are stable at room temperature for transport. Once you receive them, refrigeration is recommended to maintain long-term integrity. We package every order securely to prevent damage and ship promptly, so your vials arrive in optimal condition.
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We operate under strict in-house protocols that follow current Good Manufacturing Practices (cGMP). That means our team oversees the entire process from sourcing raw amino acids to the final lyophilized vial. Nothing is outsourced or repackaged. This gives us full control over purity, consistency, and sterility, and it’s why we can stand behind every single vial we ship.
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Store them in the refrigerator, away from direct light and heat. If you need to keep them longer, some peptides can be stored frozen. Each vial comes with clear handling instructions so you know the proper conditions for stability.
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