Thymalin

Thymalin Peptide

Thymalin is a synthetic polypeptide complex originally isolated from thymus tissue and composed of short amino acid fragments derived from thymic peptides. It is designed to mimic endogenous thymic factors involved in the regulation of immune cell differentiation, proliferation, and homeostasis. Thymalin is supplied exclusively for laboratory and analytical research use.

Overview

Thymalin represents a class of biologically active thymic peptides that are hypothesized to participate in immune system modulation by influencing T-lymphocyte differentiation and activity. In research models, it has been shown to normalize certain immunologic parameters associated with aging, stress, or immune suppression.

Laboratory studies suggest that Thymalin may act as a regulatory agent on hematopoietic stem cells and progenitor cells in the bone marrow and thymus, potentially influencing the balance between T-cell and B-cell activity. Additionally, it has been explored as a model compound for investigating thymus-derived signaling pathways, cytokine regulation, and the mechanisms of immune restoration.

Chemical Makeup

• Molecular Formula: C₁₂H₃₀N₆O₄ (approximate representative fragment for thymic peptide sequence)
• Molecular Weight: 306.41 Da (average of active fragment)
• Observed Mass (Batch # 2025022): 306.4 Da
• Purity (HPLC, LCMS-confirmed): 98.91 %
• Form: Lyophilized powder
• Analysis Method: Reverse-phase HPLC (UV 214 nm) and LCMS (ESI+ mode), calibrated with thymic peptide reference standard.
• Appearance: White to off-white crystalline powder

Research and Preclinical Studies

Thymalin and Immune Regulation

Preclinical models indicate that Thymalin may normalize T-cell and NK-cell activity, enhance phagocytic function, and regulate cytokine secretion patterns. These effects suggest a role in immune system homeostasis, particularly under conditions of age-related decline or immune dysfunction.

Thymalin and Hematopoietic Stem Cell Activity

Research has explored Thymalin’s possible ability to stimulate hematopoietic stem cells and promote their differentiation toward lymphoid lineages. This activity has been studied for its relevance in immunosenescence models and regenerative medicine contexts.

Thymalin and Anti-Inflammatory Pathways

Experimental findings suggest that Thymalin may help modulate inflammatory mediators such as interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), and interferons. Such regulation is believed to occur through thymic peptide signaling cascades influencing transcriptional control of immune response genes.

Summary

Thymalin (Batch # 2025022) demonstrates a measured molecular mass of 306.4 Da and a verified HPLC purity of 98.91 %. Analytical validation confirms this compound’s suitability for controlled laboratory investigations into immune system regulation, thymic peptide signaling, and hematopoietic cell biology. This product is intended for research use only.

References

1. Khavinson VKh, Morozov VG, et al. “Peptide bioregulators of thymic origin: mechanisms of action.” Bull Exp Biol Med. 2001;131(4):356-358. https://pubmed.ncbi.nlm.nih.gov/11443912/
   
2. Anisimov VN, Khavinson VKh, et al. “Thymic peptides and immunoregulatory activity in aging.” Mech Ageing Dev. 2002;123(8):1087-1093. https://pubmed.ncbi.nlm.nih.gov/12044938/
   
3. Khavinson VKh, et al. “Thymalin: peptide regulation of immune system and hematopoiesis.” Pathophysiology. 2005;12(3):163-169. https://pubmed.ncbi.nlm.nih.gov/16023346/
   
4. Khavinson VKh, Linkova NS, et al. “The role of thymic peptides in restoration of immune homeostasis.” Adv Gerontol. 2010;23(4):490-497. https://pubmed.ncbi.nlm.nih.gov/21360009/
   
5. Morozov VG, et al. “The immunoregulatory peptides of thymus: structural and biological properties.” Int J Immunopharmacol. 1995;17(11):803-810. https://pubmed.ncbi.nlm.nih.gov/7559161/
   
6. Khavinson VKh, Tarnovskaya SI, et al. “Clinical and experimental studies of thymic peptides.” Biogerontology. 2003;4(3):161-168. https://pubmed.ncbi.nlm.nih.gov/14501192/
   
7. Vetvicka V, et al. “Thymic peptides and innate immunity modulation.” Physiol Res. 2013;62(1):1-8. https://pubmed.ncbi.nlm.nih.gov/23047343/
   
8. National Center for Biotechnology Information. “Thymalin peptide profile.” https://pubchem.ncbi.nlm.nih.gov/compound/Thymalin
   
9. Khavinson Research Institute. “Thymalin and Epithalamin: peptide regulation of immunosenescence.” https://www.peptidebioregulator.com/research/thymalin-epithalamin-studies
   

For research use only. Not for human or veterinary use.