Triptorelin
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Size: 2mg
Contents: Triptorelin (Gonadotropin-Releasing Hormone Agonist)
Form: Powder
Purity: 99.3%
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- ENDOTOXINS(LPS)
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Triptorelin Peptide
Triptorelin is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH or LHRH) with enhanced receptor affinity and metabolic stability. It acts as a potent agonist at pituitary GnRH receptors, stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Continuous exposure leads to receptor desensitization and downregulation, making Triptorelin an established research model for studying pituitary suppression, gonadotropin regulation, and reproductive endocrinology.
Overview
Triptorelin is derived from native GnRH by substituting D-tryptophan at position 6 and ethylamide at the C-terminal glycine. These modifications increase resistance to enzymatic degradation and enhance receptor binding. In preclinical studies, Triptorelin exhibits stronger potency and longer duration of activity compared with natural GnRH and earlier analogs such as Buserelin.
It is widely utilized in experimental endocrinology to investigate pituitary–gonadal feedback, puberty suppression, fertility control, and hormone-dependent tumor models.
Chemical Makeup
- Molecular Formula: C64H82N18O13
- Molecular Weight: 1311.5 g/mol
- Amino Acid Sequence: Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂
- Compound Class: Synthetic GnRH analog (decapeptide)
- Form: Lyophilized powder
- Purity: ≥99% (per COA)
- Sizes Available: 2mg, 5mg, 10mg vials
Research and Clinical Studies
Pituitary and Gonadal Axis Regulation
Triptorelin binds GnRH receptors on anterior pituitary gonadotrophs, triggering the release of LH and FSH. Prolonged stimulation causes receptor desensitization, resulting in suppressed gonadotropin secretion — a model for studying reversible hypogonadotropic states.
Reproductive and Fertility Research
Triptorelin is used to investigate mechanisms underlying ovulation, spermatogenesis, and hormonal control of reproduction. Pulsatile exposure mimics physiological GnRH release, whereas continuous exposure allows suppression models.
Endocrine and Tumor Biology
Continuous Triptorelin exposure has been studied for suppression of gonadal steroidogenesis in hormone-dependent cancer models (e.g., prostate and breast cancer), providing insight into androgen and estrogen deprivation pathways.
Pubertal and Neuroendocrine Studies
In developmental endocrinology, Triptorelin serves as a reference peptide for analyzing pubertal onset, hypothalamic control of GnRH neurons, and receptor downregulation kinetics.
Pharmacokinetics
Triptorelin demonstrates higher receptor binding affinity and slower plasma clearance than native GnRH, contributing to prolonged biological effects in controlled research applications.
Triptorelin peptide is available for research and laboratory purposes only. Not for human consumption.
References
- Sandow J, et al. Triptorelin: a potent LHRH agonist with prolonged activity. J Med Chem. 1985;28(6):999–1002. https://pubmed.ncbi.nlm.nih.gov/3922268/
- Bouchard P, et al. Mechanisms of action of GnRH agonists in endocrine regulation. Hum Reprod. 1989;4(2):180–188. https://pubmed.ncbi.nlm.nih.gov/2660129/
- Millar RP, et al. GnRH receptor pharmacology and desensitization. Front Neuroendocrinol. 2004;25(1):1–23. https://pubmed.ncbi.nlm.nih.gov/15068814/
- Limonta P, et al. Triptorelin and the regulation of LH/FSH secretion in experimental models. Mol Cell Endocrinol. 1990;73(1):77–84. https://pubmed.ncbi.nlm.nih.gov/2127493/
- Marshall JC, et al. Downregulation of pituitary receptors following GnRH agonist exposure. Endocr Rev. 1993;14(1):90–110. https://pubmed.ncbi.nlm.nih.gov/8381109/
- Redding TW, et al. Comparative potency of LHRH analogs in animal studies. Endocrinology. 1984;115(1):250–254. https://pubmed.ncbi.nlm.nih.gov/6428703/
- Aubert ML, et al. Pituitary responses to GnRH analog stimulation and suppression. Neuroendocrinology. 1986;44(1):36–42. https://pubmed.ncbi.nlm.nih.gov/3510800/
- Naor Z. Signaling pathways activated by GnRH receptors. Trends Endocrinol Metab. 2009;20(2):60–70. https://pubmed.ncbi.nlm.nih.gov/19138580/
- Plant TM, et al. Neuroendocrine regulation of puberty and GnRH pulse generation. Front Neuroendocrinol. 2012;33(3):254–276. https://pubmed.ncbi.nlm.nih.gov/22584057/
- Millar RP. GnRH analogues: structures and clinical implications. Front Neuroendocrinol. 2005;26(2):115–146. https://pubmed.ncbi.nlm.nih.gov/16009469/
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How do I know the peptides I order are exactly what the label says?
Every vial we sell comes from a lab that follows current Good Manufacturing Practices (cGMP). That means each step of production is documented and controlled. Before a batch is released, it’s tested by independent third-party labs for purity, identity, and sterility. Certificates of analysis are available so you can see the exact test results.
Are your peptides produced in a sterile and controlled environment?
Yes. The labs we work with use ISO-certified clean rooms where air quality, equipment, and handling procedures are tightly regulated. Staff are trained to pharmaceutical-grade standards. This ensures the peptides are produced in an environment that minimizes contamination risks.
What about shipping? Do the peptides remain stable in transit?
Peptides in lyophilized (freeze-dried) form are stable at room temperature for transport. Once you receive them, refrigeration is recommended to maintain long-term integrity. We package every order securely to prevent damage and ship promptly, so your vials arrive in optimal condition.
How do I know you actually make these peptides yourselves?
We operate under strict in-house protocols that follow current Good Manufacturing Practices (cGMP). That means our team oversees the entire process from sourcing raw amino acids to the final lyophilized vial. Nothing is outsourced or repackaged. This gives us full control over purity, consistency, and sterility, and it’s why we can stand behind every single vial we ship.
What should I do with the vials once they arrive?
Store them in the refrigerator, away from direct light and heat. If you need to keep them longer, some peptides can be stored frozen. Each vial comes with clear handling instructions so you know the proper conditions for stability.
What proof do you have that your peptides are legitimate?
The strongest proof is transparency. For every peptide, we can provide certificates of analysis, manufacturing documentation, and references to the published scientific research behind it. If you ever have questions, we’ll show you the data rather than ask you to take our word for it.